NF-κB canonical signaling pathway-ELK Biotechnology CO.,Ltd.

Technical

NF-κB canonical signaling pathway

source：Technical division

date：2022-07-21

NF-kB (k-hammer enhancement of nuclear factor-activated B cells) plays a key regulatory role in cytokine-induced gene expression, and it regulates genes encoding: acute phase response proteins, cytokines, cell adhesion molecules , immune regulatory molecules, viral oncogenes, growth factors, transcription and growth regulators, etc. By regulating the expression of various genes, NF-kB is involved in various biological processes such as immune response, inflammatory response, apoptosis, and tumorigenesis.

The NF-kB family consists of cRel, RelA (p65), RelB, NF-kB1 (p50), NF-kB2 (p52), and they all have Rel homology domains at the N-terminus, among which cReI, ReIA (p65) and ReIB has a transcription activation domain (TAD), which can positively regulate gene expression; p52 and p50 are cleaved from the precursor proteins p100 and p105, respectively, and the C-terminus of the precursor protein has a structure similar to NF-kB inhibitor (IκB) , as IkB-like proteins inhibit NF-kB function, and their homodimers can inhibit transcription.

Indicator name	reactivity	application
NFκB p65 mAb（5G6）	H.M.R	WB.IHC-p.IF/ICC.IP
NFκB-p65 pAb	H.M.R	WB.IHC-p.lF(P).IP.ELISA
NFκB-p65 (Thr505) pAb	H.M.R	WB.IHC-p.lF(P).ELISA
NFκB-p65 (Thr435) pAb	H.MRMκ	WB.IHC-p.IF(P).IP ELISA
NFκB-p65 (Thr254) pAb	H.M.R	WB.IHC-p.lF(P).IP ELISA
NFκB-p65 (Sec536) pAb	H.M.R.Mκ	IF/ICC.WB.IHC-p.IP.ELISA
NFκB-p65 (Ser529) pAb	H.M.R.Mκ	IF/ICC.WB.IHC-p.ELISA
NFκB-p65 (Ser468) pAb	H.M.R	WB.IHC-p.IF(P).IP ELISA
NFκB-p65 (Ser311) pAb	H.M	WB.IHC-p.IF/ICC.ELISA
NFκB-p65(Ser281)pAb	H.M.R	IHC-p.lF(P).ELISA
NFκB-p65 (Ser276) pAb	H.M.R	WB.IHC-p.lF(P).lP.ELISA
RelB (Ser552) pAb	H.M	WB.IHC-p.lF(P).ELISA
RelB pAb	H.M	WB.ELISA
c-Rel mAb	H.M	WB.IHC-p.IF/ICC.ELlSA
c-Rel pAb	H.R.M.	WB.IHC-p.lF(P).ELISA
c-Rel (Ser503) pAb	H.R.M.	WB.IHC-p.lF(P).ELISA
NF-κB P105/P50 M mAb(4D11)	H. M	IHC-p.WB
NFκB-p105/p50mAb	H	WB.IHC-p.IF/lCC.FCM.ELISA
NFκB-p105/p50pAb	H.M.R	IF/ICC.WB.IHC-p.ELISA
NFκB-p105/p50 (Ser337) pAb	H.M.R	WB.IHC-p.IF/ICC.ELISA
NFκB-p105(Ser932)pAb	H.M.R	WB.IHC-p.lF(P).ELISA
NFκB-p105(Ser927)pAb	H.M	WB.IHC-p.IF/ICC.ELISA
NFκ0-p105 (Ser907) pAb	H.R.M.	WB.IHC-p.lF(P).IP.ELISA
NFκB-p105 (Ser893) pAb	H.R.M.	WB.IHC-p.lF(P).ELISA
NF-κB p105 (Ser923) rabbit pAb	H.M	WB. ELISA
NF-κB p105 (Ser903) rabbit pAb	H.M	WB. ELISA
NF-κB p105 (Cleaved-Thr434) rabbit pAb	H.M	WB. ELISA
NF-κB p105 (Cleaved-Gly433) rabbit pAb	H.M	WB. ELISA
NF-κB2 p100 (-Ser866/870) rabbit pAb	H.M	WB
NFκB-p100 (Ser865) pAb	H.M.R	WB.IHC-p.IP.IF/lCC.ELISA
NFκB-p100 (Ser869) pAb	H.M.R	WB.IHC-p.lF(P).IP.ELISA
NFκB-p100 (Ser872) pAb	H.M	WB.ELISA
NFκB-p100 pAb	H.M.R	WB.IHC-p.IP.IF/ICC.ELISA
IKKα mAb	H	WB.IF/ICC.FCM.ELISA
IKKα/β pAb	H.M.R	WB.IHC-p.IF(P).ELISA
IKKα (Thr23) pAb	H.M.R	WB.IHC-p.lF(P).ELISA
IKKα pAb	H.M.R	WB.IHC-p.lF(P).ELISA
IKKα/β (Ser176/177) pAb	H.M.R	WB.IHC-p.IF(P).ELISA
IKKα/β (Ser180/181) pAb	H.M.R	WB.IHC-p.lF(P).ELISA
IKKβ pAb	H.M.R	WB.IHC-p.lF(P).ELlSA
IKKβ mAb	H	WB.IHC-p.lF(P).ELISA
IKKβ (lyr199) pAb	H.M.R	WB.IHC-p.IF(P).ELISA
IKKβ (Tyr188) pAb	H.M.R.Mκ	WB.IHC-p.IF(P).ELISA
IKKγ pAb	H.M.R	WB.IHC-p.lF(P).ELISA
IKKγ (Ser85) pAb	H.R.M.	WB.IHC-p.IF(P).ELlSA
IKKγ (Ser376) pAb	H.R.M.	IHC-p.IF(P).ELISA
IKKγ (Ser31) pAb	H.R.M.	WB.IHC-p.lF(P).ELISA
IκB α M mAb(2A5)	H. M.R	IHC-p.WB
IκB-α pAb	H.M.R	WB.IHC-p.IF/lCC.ELISA
IκBα (-Ser32) rabbit pAb	H.M.R	WB
lκB-α (Tyr42) pAb	H.M.R	WB.IHC-p.lF(P).ELISA
IκB-α (Tyr305) pAb	H.M.R.Mκ	WB.IHC-p.lF(P).ELISA
IκB-α (Ser32/S36) pAb	H.M.R.Mκ	WB.IHC-p.IF/ICC.ELISA

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