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MYO15 rabbit pAb
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ES9857
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MYO15 rabbit pAb
Reactivity: Human;Mouse
Source: Rabbit
Dilutions: IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human protein . at AA range: 2990-3070
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 388kD
GeneID: 51168
Human Swiss-Prot No: Q9UKN7
Cellular localization: Cell projection, stereocilium . Cytoplasm, cytoskeleton . Localizes to stereocilium tips in cochlear and vestibular hair cells. .
Background: This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008],