Synthesized peptide derived from human protein . at AA range: 180-260
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
177kD
GeneID:
53904
Human Swiss-Prot No:
Q8NEV4
Cellular localization:
Cytoplasm, cytoskeleton. Cytoplasm . Cell projection, filopodium tip . Cell projection, stereocilium . Increased localization at the filodium tip seen in the presence of MORN4. .
Background:
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008],
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