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MUC5A rabbit pAb
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ES9826
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MUC5A rabbit pAb
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilutions: IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human protein . at AA range: 4400-4480
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 553kD
Human Swiss-Prot No: P98088
Cellular localization: Secreted .
Background: domain:The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.,function:Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system.,PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.,PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 2 VWFC domains.,similarity:Contains 4 VWFD domains.,subunit:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).,tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.,