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LRP2 rabbit pAb
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ES9778
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50 µL $148.00
100 µL $248.00
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Overview

Product name: LRP2 rabbit pAb
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilutions: IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human protein . at AA range: 2890-2970
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 512kD
GeneID: 4036
Human Swiss-Prot No: P98164
Cellular localization: Apical cell membrane ; Single-pass type I membrane protein . Endosome lumen . Membrane, coated pit . Cell projection, dendrite . Cell projection, axon . Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. .
Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of th