Synthesized peptide derived from human protein . at AA range: 470-550
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
75kD
GeneID:
6049
Human Swiss-Prot No:
Q9Y252
Cellular localization:
Nucleus . Cytoplasm . Cell projection, axon . Nucleus, PML body . Localizes to the PML nuclear bodies in Sertoli cells. .
Background:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008],
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