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MBP rabbit pAb
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ES8978
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MBP rabbit pAb
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilutions: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human protein . at AA range: 180-260
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 33kD
GeneID: 4155
Human Swiss-Prot No: P02686
Cellular localization: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.; [Isoform 3]: Nucleus . Targeted to nucleus in oligodendrocytes.
Background: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that