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Claudin 11 Antibody
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ES8914
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Claudin 11 Antibody
Reactivity: Human;Mouse;Rat
Alternative Names: Claudin-11 (Oligodendrocyte-specific protein)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from human Claudin 11
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 20kD
GeneID: 5010
Human Swiss-Prot No: O75508
Cellular localization: Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso