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VE-Cadherin rabbit pAb
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ES8908
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50 µL $148.00
100 µL $248.00
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Overview

Product name: VE-Cadherin rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from human VE-Cadherin Polyclonal AA range: 30-110
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 1003
Human Swiss-Prot No: P33151
Cellular localization: Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. .
Background: This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],