Products

PEK/PERK rabbit pAb
One-click to copy product information
ES8906
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: PEK/PERK rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from human PEK/PERK Polyclonal
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 9451
Human Swiss-Prot No: Q9NZJ5
Cellular localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],