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CD42c rabbit pAb
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ES8786
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CD42c rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Platelet glycoprotein Ib beta chain (GP-Ib beta;GPIb-beta;GPIbB;Antigen CD42b-beta;CD antigen CD42c)
Source: Rabbit
Dilutions: IHC-p 1:50-200, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 90-150
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID: 2812
Human Swiss-Prot No: P13224
Cellular localization: Membrane; Single-pass type I membrane protein.
Background: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, t