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Insulin rabbit pAb
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ES8775
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Insulin rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Source: Rabbit
Dilutions: IHC-p 1:50-200, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 30-70
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID: 3630
Human Swiss-Prot No: P01308
Cellular localization: Secreted.
Background: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],