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HLA-DQA1 rabbit pAb
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ES8761
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50 µL $148.00
100 µL $248.00
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Overview

Product name: HLA-DQA1 rabbit pAb
Reactivity: Human
Alternative Names: HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain;DC-alpha;HLA-DCA;MHC class II DQA1)
Source: Rabbit
Dilutions: IHC-p 1:50-200, ELISA 1:10000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQA1. AA range:21-70
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID: 100509457
Human Swiss-Prot No: P01909
Cellular localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Background: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro