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VHL rabbit pAb
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ES8746
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50 µL $148.00
100 µL $248.00
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Overview

Product name: VHL rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Von Hippel-Lindau disease tumor suppressor (Protein G7;pVHL)
Source: Rabbit
Dilutions: IHC-p 1:50-200, ELISA 1:10000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human VHL. AA range:1-50
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID: 7428
Human Swiss-Prot No: P40337
Cellular localization: [Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; [Isoform 3]: Cytoplasm. Nucleus. Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
Background: von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],