| Product name: |
IL-27A rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
Interleukin-27 subunit alpha (IL-27 subunit alpha;IL-27-A;IL27-A;p28) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 1-50 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| GeneID: |
246778 |
| Human Swiss-Prot No: |
Q8NEV9 |
| Cellular localization: |
Secreted . Does not seem to be secreted without coexpression of EBI3. |
| Background: |
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008], |
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