| Product name: |
LT-β rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
Lymphotoxin-beta (LT-beta;Tumor necrosis factor C;TNF-C;Tumor necrosis factor ligand superfamily member 3) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, ELISA 1:10000-20000,WB 1:500-2000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 41-90 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| GeneID: |
4050 |
| Human Swiss-Prot No: |
Q06643 |
| Cellular localization: |
Membrane ; Single-pass type II membrane protein . |
| Background: |
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
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