Products

TGFβ2 rabbit pAb
One-click to copy product information
ES8706
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: TGFβ2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Transforming growth factor beta-2 (TGF-beta-2;BSC-1 cell growth inhibitor;Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;Polyergin)
Source: Rabbit
Dilutions: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 47+12kD
GeneID: 7042
Human Swiss-Prot No: P61812
Cellular localization: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-2]: Secreted .
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the an