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Tcl1 rabbit pAb
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ES8608
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Tcl1 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 30-110
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 13kD
GeneID: 8115
Human Swiss-Prot No: P56279
Cellular localization: Cytoplasm . Nucleus . Microsome . Endoplasmic reticulum . Microsomal fraction.
Background: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],