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COL25A1 rabbit pAb
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ES8542
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50 µL $148.00
100 µL $248.00
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Overview

Product name: COL25A1 rabbit pAb
Reactivity: Human;Mouse
Alternative Names: COL25A1
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 101-150
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 64kD
GeneID: 84570
Human Swiss-Prot No: Q9BXS0
Cellular localization: Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
Background: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],