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SPOP rabbit pAb
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ES8522
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50 µL $148.00
100 µL $248.00
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Overview

Product name: SPOP rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SPOP. AA range:41-90
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 42kD
GeneID: 8405
Human Swiss-Prot No: O43791
Cellular localization: Nucleus . Nucleus speckle .
Background: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],