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C8 β rabbit pAb
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ES8518
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Overview

Product name: C8 β rabbit pAb
Reactivity: Human;Rat
Alternative Names: Complement component C8 beta chain (Complement component 8 subunit beta)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human C8B. AA range:371-420
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 70kD
GeneID: 732
Human Swiss-Prot No: P07358
Cellular localization: Secreted.
Background: This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],