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TRIF rabbit pAb
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ES8501
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50 µL $148.00
100 µL $248.00
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Overview

Product name: TRIF rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: TIR domain-containing adapter molecule 1 (TICAM-1;Proline-rich, vinculin and TIR domain-containing protein B;Putative NF-kappa-B-activating protein 502H;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;TIR domain-containing adapter protein inducing IFN-beta)
Source: Rabbit
Dilutions: WB 1:500-2000,IHC-p 1:50-200 ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from TRIF at AA range: 663-712
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 80kD
GeneID: 148022
Human Swiss-Prot No: Q8IUC6
Cellular localization: Cytoplasmic vesicle, autophagosome . Cytoplasm, cytosol . Mitochondrion . Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). .
Background: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012],