Products

Collagen IV rabbit pAb
One-click to copy product information
ES8486
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: Collagen IV rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: collagen, type IV, alpha 1
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from Collagen IV . at AA range: 1428-1443
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 1282
Human Swiss-Prot No: P02462
Cellular localization: Secreted, extracellular space, extracellular matrix, basement membrane .
Background: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],