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Cleaved-CD97α (L530) rabbit pAb
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ES8096
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Cleaved-CD97α (L530) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: CD97; CD97 antigen; Leukocyte antigen CD97; CD antigen CD97
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CD97alpha. AA range:481-530
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 55kD
GeneID: 976
Human Swiss-Prot No: P48960
Cellular localization: Cell membrane ; Multi-pass membrane protein .; [Adhesion G protein-coupled receptor E5 subunit alpha]: Secreted, extracellular space .
Background: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 1