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Neurocalcin δ rabbit pAb
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ES7722
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Overview

Product name: Neurocalcin δ rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: NCALD; Neurocalcin-delta
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from Neurocalcin δ . at AA range: 370-450
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 22kD
GeneID: 83988
Human Swiss-Prot No: P61601
Cellular localization: intracellular,cytosol,clathrin coat of trans-Golgi network vesicle,extracellular exosome,
Background: This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008],