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CHSY2 rabbit pAb
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ES7583
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CHSY2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: CHPF; CSS2; Chondroitin sulfate synthase 2; Chondroitin glucuronyltransferase 2; Chondroitin-polymerizing factor; ChPF; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-pro
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CHSY2. AA range:631-680
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 85kD
GeneID: 79586
Human Swiss-Prot No: Q8IZ52
Cellular localization: [Isoform 1]: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Cytoplasm, cytosol .; [Isoform 3]: Cytoplasm, cytosol . Mitochondrion .; [Isoform 2]: Mitochondrion matrix .
Background: catalytic activity:UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.,catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.,cofactor:Divalent cations. Highest activities are measured with manganese. Can also utilize cobalt.,function:Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer.,online information:GlycoGene database,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,subunit:Binds CHSY1.,tissue specificity:Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, small intestine and placenta.,