PTPα (phospho Tyr798) rabbit pAb

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PTPα (phospho Tyr798) rabbit pAb

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ES6938

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	PTPα (phospho Tyr798) rabbit pAb
Reactivity:	Human;Mouse;Rat;Monkey
Alternative Names:	PTPRA; PTPA; PTPRL2; Receptor-type tyrosine-protein phosphatase alpha; Protein-tyrosine phosphatase alpha; R-PTP-alpha
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:	The antiserum was produced against synthesized peptide derived from human PTPRA around the phosphorylation site of Tyr798. AA range:753-802
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	100 90kD
GeneID:	5786
Human Swiss-Prot No:	P18433
Cellular localization:	Cell membrane ; Single-pass type I membrane protein . Cell junction, focal adhesion . Localizes to focal adhesion sites following integrin engagement. .
Background:	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],

Western blot analysis of lysates from HeLa cells treated with serum 20% 15', using PTPRA (Phospho-Tyr798) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).