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PAF-R rabbit pAb
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ES6880
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PAF-R rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
Source: Rabbit
Dilutions: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 39kD
GeneID: 5724
Human Swiss-Prot No: P25105
Cellular localization: Cell membrane ; Multi-pass membrane protein .
Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],