Products

Saposin rabbit pAb
ES6845
Size： Price：
50 µL $148.00
100 µL $248.00
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Overview

Product name: Saposin rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: PSAP; GLBA; SAP1; Proactivator polypeptide
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PSAP. AA range:307-356
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 58kD
GeneID: 5660
Human Swiss-Prot No: P07602
Cellular localization: Lysosome .; [Prosaposin]: Secreted . Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. .
Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],