Products

Arkadia rabbit pAb
One-click to copy product information
ES6675
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: Arkadia rabbit pAb
Reactivity: Human;Mouse
Alternative Names: RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 110kD
GeneID: 54778
Human Swiss-Prot No: Q6ZNA4
Cellular localization: Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .
Background: ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],