Pim-1 rabbit pAb

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Pim-1 rabbit pAb

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ES6589

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	Pim-1 rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	PIM1; Serine/threonine-protein kinase pim-1
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human Pim-1. AA range:281-330
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	50kD
GeneID:	5292
Human Swiss-Prot No:	P11309
Cellular localization:	[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.
Background:	The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],

Western blot analysis of lysates from Jurkat cells, using Pim-1 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).