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Pim-1 (phospho Tyr309) rabbit pAb
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ES6588
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Pim-1 (phospho Tyr309) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: PIM1; Serine/threonine-protein kinase pim-1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Pim-1 around the phosphorylation site of Tyr309. AA range:281-330
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 45kD
GeneID: 5292
Human Swiss-Prot No: P11309
Cellular localization: [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.
Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],