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PHKB rabbit pAb
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ES6585
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PHKB rabbit pAb
Reactivity: Human;Mouse
Alternative Names: PHKB; Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human KPBB. AA range:661-710
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 124kD
GeneID: 5257
Human Swiss-Prot No: Q93100
Cellular localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency