Sclerostin rabbit pAb

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Sclerostin rabbit pAb

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ES6491

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	Sclerostin rabbit pAb
Reactivity:	Human;Rat;Mouse;
Alternative Names:	SOST; Sclerostin
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:	Synthesized peptide derived from Sclerostin . at AA range: 130-210
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	26kD
GeneID:	50964
Human Swiss-Prot No:	Q9BQB4
Cellular localization:	Secreted, extracellular space, extracellular matrix .
Background:	Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],

Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°over night
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).