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AZ1 rabbit pAb
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ES6440
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50 µL $148.00
100 µL $248.00
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Overview

Product name: AZ1 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000,WB 1:500-2000
Immunogen: The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 25kD
GeneID: 4946
Human Swiss-Prot No: P54368
Cellular localization: nucleus,cytoplasm,cytosol,
Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms