| Product name: |
MEL-1A-R rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human MTR1A. AA range:191-240 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
39kD |
| GeneID: |
4543 |
| Human Swiss-Prot No: |
P48039 |
| Cellular localization: |
Cell membrane; Multi-pass membrane protein. |
| Background: |
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008], |
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