| Product name: |
VE-Cadherin rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD144 |
| Source: |
Rabbit |
| Dilutions: |
IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human CDH5. AA range:391-440 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
86kD |
| GeneID: |
1003 |
| Human Swiss-Prot No: |
P33151 |
| Cellular localization: |
Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. . |
| Background: |
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015], |
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