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PSGL-1 rabbit pAb
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ES4302
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PSGL-1 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 45 110kd(glycosylated)
GeneID: 6404
Human Swiss-Prot No: Q14242
Cellular localization: Membrane; Single-pass type I membrane protein.
Background: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011],