Products

Wnt-1 rabbit pAb
One-click to copy product information
ES3706
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: Wnt-1 rabbit pAb
Reactivity: Human;Mouse
Alternative Names: WNT1; INT1; Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human WNT1. AA range:301-350
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 45kD
GeneID: 7471
Human Swiss-Prot No: P04628
Cellular localization: Secreted, extracellular space, extracellular matrix . Secreted .
Background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in