| Product name: |
Tyk 2 rabbit pAb |
| Reactivity: |
Human;Mouse;Monkey |
| Alternative Names: |
TYK2; Non-receptor tyrosine-protein kinase TYK2 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human TYK2. AA range:1020-1069 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
134kD |
| GeneID: |
7297 |
| Human Swiss-Prot No: |
P29597 |
| Cellular localization: |
nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome, |
| Background: |
tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008], |
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