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Neurofibromin rabbit pAb
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ES2930
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Neurofibromin rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: NF1; Neurofibromin; Neurofibromatosis-related protein NF-1
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 319kD
GeneID: 4763
Human Swiss-Prot No: P21359
Cellular localization: Nucleus . Nucleus, nucleolus .
Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],