Sin3B rabbit pAb

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Sin3B rabbit pAb

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ES2858

Size：	Price：
50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	Sin3B rabbit pAb
Reactivity:	Human;Rat;Mouse;
Alternative Names:	SIN3B; KIAA0700; Paired amphipathic helix protein Sin3b; Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:	The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	130kD
GeneID:	23309
Human Swiss-Prot No:	O75182
Cellular localization:	Nucleus .
Background:	function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,

Western Blot analysis of various cells using Sin3B Polyclonal Antibody
Immunofluorescence analysis of HeLa cells, using SIN3B Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from A549 cells, using SIN3B Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).