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Melanopsin rabbit pAb
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ES2777
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Melanopsin rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: OPN4; MOP; Melanopsin; Opsin-4
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from human OPN4. AA range:429-478
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 55kD
GeneID: 94233
Human Swiss-Prot No: Q9UHM6
Cellular localization: Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell projection, dendrite . Perikaryon .
Background: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by Ref