| Product name: |
FAST rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
FASTK; Fas-activated serine/threonine kinase; FAST kinase |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
61kD |
| GeneID: |
10922 |
| Human Swiss-Prot No: |
Q14296 |
| Cellular localization: |
[Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. . |
| Background: |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008], |
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