Product name: |
D4DR rabbit pAb |
Reactivity: |
Human;Mouse;Rat |
Alternative Names: |
DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
Source: |
Rabbit |
Dilutions: |
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404 |
Storage: |
-20°C/1 year |
Clonality: |
Polyclonal |
Isotype: |
IgG |
Concentration: |
1 mg/ml |
Observed Band: |
48kD |
GeneID: |
1815 |
Human Swiss-Prot No: |
P21917 |
Cellular localization: |
Cell membrane ; Multi-pass membrane protein . |
Background: |
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008], |