| Product name: |
Cytokeratin 13 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
KRT13; Keratin; type I cytoskeletal 13; Cytokeratin-13; CK-13; Keratin-13; K13 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human Cytokeratin 13. AA range:233-282 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
52kD |
| GeneID: |
3860 |
| Human Swiss-Prot No: |
P13646 |
| Cellular localization: |
nucleus,intermediate filament,keratin filament,intermediate filament cytoskeleton,extracellular exosome, |
| Background: |
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008], |
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