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AMPKα2 rabbit pAb
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ES20835
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50 µL $148.00
100 µL $248.00
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Overview

Product name: AMPKα2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
Source: Rabbit
Dilutions: WB: 1:1000-2000
Immunogen: Recombinant Protein of AMPKα2
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 62kD
GeneID: 5563
Human Swiss-Prot No: P54646
Cellular localization: Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],