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AMPKβ2 rabbit pAb
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ES20834
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Overview

Product name: AMPKβ2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2
Source: Rabbit
Dilutions: WB: 1:1000-2000
Immunogen: Recombinant Protein of AMPKβ2
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 30kD
GeneID: 5565
Human Swiss-Prot No: O43741
Cellular localization: nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],