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Bestrophin-1 rabbit pAb
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ES20817
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Bestrophin-1 rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: Bestrophin-1 (TU15B;Vitelliform macular dystrophy protein 2)
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: Synthetic Peptide of Bestrophin-1 AA range: 161-211
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 67kD
GeneID: 7439
Human Swiss-Prot No: O76090
Cellular localization: Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane .
Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],