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Crystallin-αC rabbit pAb
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ES20776
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Crystallin-αC rabbit pAb
Reactivity: Human
Alternative Names: HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
Source: Rabbit
Dilutions: WB: 1:500-1000
Immunogen: Recombinant Protein of Crystallin-αC
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 22kD
GeneID: 26353
Human Swiss-Prot No: Q9UJY1
Cellular localization: Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
Background: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],